Deselection of substances
Following expert review of additional data that has come forward, OSPAR has removed several substances from the List of Substances of Possible Concern since it was first published. Information on these substances and the reasons for their removal can be found on the List of Substances Removed from the OSPAR List of Substances of Possible Concern (Reference number 2004-13).
The fact sheets for the deselected substances have been updated to include information about the reasons for deselection. Following this the fact sheets have been removed from the website and will not be updated any further. They are stored in the database of the OSPAR Secretariat and can be made available upon request to the Secretariat.
Visitors to this website who have information that would enable OSPAR to update its List of Substances of Possible Concern are invited to contact the OSPAR Secretariat who will advise them further regarding the submission of relevant information. An empty fact sheet for the submission of such information and a glossary explaining the content of the fact sheet are available for downloading.
NB: The List of substances of possible concern is under review.
Substances removed from the OSPAR List of Substances of Possible Concern
Annotations in the last column indicate that the substance belongs to a group of substances on the OSPAR List of Chemicals for Priority Action as follows:
* PAHS, † Organic Tin Compounds, ‡ PCBs
CAS No. | Name | Synonym | Function or use category | Deselected by | |
---|---|---|---|---|---|
79-74-3 | 1,4-benzenediol, 2,5-bis(1,1-dimethylpropyl)- | Phenol | HSC 2004 | ||
80-56-8 | Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl- | Alpha pinene | Aliphatic hydrocarbon | HSC 2008 | |
81-96-9 | 7H-benz[de]anthracen-7-one, 3-bromo- | Organohalogen | HSC 2004 | ||
91-57-6 | naphthalene, 2-methyl- | ß-methylnaphthalene | PAH | HSC 2004 | * |
92-86-4 | 1,1'-biphenyl, 4,4'-dibromo- | Organohalogen | HSC 2004 | ||
93-79-8 | acetic acid, (2,4,5-trichlorophenoxy)-, butyl ester | butyl 2,4,5-T | Pesticide | HSC 2004 | |
107-46-0 | Hexamethyldisiloxane | HMDS | Organosilicane | HSC(1) 2007 | |
120-39-8 | acetic acid, (2,4,5-trichlorophenoxy)-, pentyl ester | 2,4,5-T esters | Pesticide | HSC 2004 | |
123-48-8 | 3-heptene, 2,2,4,6,6-pentamethyl- | Aliphatic hydrocarbon | HSC 2004 | ||
127-25-3 | 1-phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, [1R-(1.alpha.,4a.beta.,4b.alpha.,10a.alpha.)]- | abietic acid methyl ester | PAH | HSC 2004 | * |
127-36-6 | 1-phenanthrenemethanol, 1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a-dimethyl-7-(1-methylethyl)- | PAH | HSC 2004 | * | |
134-83-8 | benzene, 1-chloro-4-(chlorophenylmethyl)- | Organohalogen | HSC 2004 | ||
194-59-2 | 7H-dibenzo[c,g]carbazole | PAH | HSC 2004 | * | |
239-64-5 | 13H-dibenzo[a,i]carbazole | PAH | HSC 2004 | * | |
315-37-7 | androst-4-en-3-one, 17-[(1-oxoheptyl)oxy]-, (17.beta.)- | testosterone-enantate- (INNM) | Hormone | HSC 2004 | |
469-61-4 | 1H-3a,7-methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, [3R-(3alpha,3abeta,7beta,8aalpha)]- | alpha.-cedrene | PAH | HSC 2004 | * |
485-31-4 | 2-butenoic acid, 3-methyl-, 2-(1-methylpropyl)-4,6-dinitrophenyl ester | binapacryl | Pesticide | HSC 2004 | |
515-69-5 | 3-cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (R*,R*)- | bisabolol | Aliphatic hydrocarbon | HSC 2004 | |
563-12-2 | phosphorodithioic acid, S,S'-methylene O,O,O',O'-tetraethyl ester | ethion | Pesticide | HSC 2004 | |
612-83-9 | [1,1'-biphenyl]-4,4'-diamine, 3,3'-dichloro-, dihydrochloride | Organohalogen | HSC 2004 | ||
634-83-3 | benzenamine, 2,3,4,5-tetrachloro- | Organohalogen | HSC 2004 | ||
666-84-2 | 1-phenanthrenemethanol, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1.alpha.,4a.beta.,4b.alpha.,10a.alpha.)]- | PAH | HSC 2004 | * | |
786-19-6 | phosphorodithioic acid, S-[[(4-chlorophenyl)thio]methyl] O,O-diethyl ester | carbophenthion | Pesticide | HSC 2004 | |
947-72-8 | phenanthrene, 9-chloro- | Organohalogen | HSC 2004 | ||
1330-78-5 | phosphoric acid, tris(methylphenyl) ester | tricresylphosphate | Organophosphate | HSC 2004 | |
2050-68-2 | 1,1'-biphenyl, 4,4'-dichloro- | Organohalogen | HSC 2004 | ‡ | |
3081-14-9 | 1,4-benzenediamine, N,N'-bis(1,4-dimethylpentyl)- | Organic nitrogen compound | HSC 2004 | ||
3090-36-6 | stannane, tributyl(1-oxododecyl)oxy- | tributyltin laurate | pesticide | HSC 2004 | † |
3178-22-1 | cyclohexane, (1,1-dimethylethyl)- | Aliphatic Hydrocarbon | HSC 2004 | ||
3481-20-7 | benzenamine, 2,3,5,6-tetrachloro- | Organohalogen | HSC 2004 | ||
4098-71-9 | cyclohexane, 5-isocyanato-1(isocyanatomethyl)-1,3,3-trimethyl- | SPS 2002 | |||
5208-93-5 | 1,4-pentadien-3-ol, 3-methyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)- | vinyl-.beta.-ionol | Aliphatic hydrocarbon | HSC 2004 | |
6119-92-2 | 2-butenoic acid, 2-(1-methylheptyl)-4,6-dinitrophenyl ester | Organic nitrogen compound | HSC 2004 | ||
7212-44-4 | 1,6,10-dodecatrien-3-ol, 3,7,11-trimethyl- | nerolidol | Pesticide | HSC 2004 | |
10457-90-6 | bromperidol | Organohalogen | HSC 2004 | ||
11028-42-5 | cedrene- | PAH | HSC 2004 | * | |
13393-93-6 | 1-phenanthrenemethanol, tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)- | abietyl alcohol, tetrahydro- | PAH | HSC 2004 | * |
13475-82-6 | heptane, 2,2,4,6,6-pentamethyl- | Aliphatic hydrocarbon | HSC 2004 | ||
15233-47-3 | 1,4-benzenediamine, N-(1-methylheptyl)-N'-phenyl- | Organic nitrogen compound | HSC 2004 | ||
16938-22-0 | hexane, 1,6-diisocyanato-2,2,4-trimethyl- | SPS 2002 | |||
17354-14-2 | 9,10-anthracenedione, 1,4-bis(butylamino)- | C.I. Solvent Blue 35 | Organic nitrogen compound | HSC 2004 | |
18379-25-4 | silane, trichloro(2,4,4-trimethylpentyl)- | Organohalogen | HSC 2004 | ||
19666-30-9 | 1,3,4-Oxadiazol-2(3H)-one, 3-[2,4-dichloro-5-(1-methylethoxy)phenyl]-5-(1,1-dimethylethyl)- | oxidiazon | Pesticide | HSC 2005 | |
19941-28-7 | 1-phenanthrenecarboxylic acid, tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, [1R-(1alpha,4abeta,4balpha | methyl tetrahydroabietate | PAH | HSC 2004 | * |
21850-44-2 | Benzene, 1,1'-(1-methylethylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)- | Organohalogen | HSC 2009 | ||
23089-26-1 | 3-cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, [S-(R1,R1)]- | levomenol | Aliphatic hydrocarbon | HSC 2004 | |
25428-43-7 | 3-cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (R*,R*)-(.+-.)- | Pesticide | HSC 2004 | ||
28553-12-0 | 1,2-Benzenedicarboxylic acid, diisononyl ester | DINP | Phthalates | HSC(1) 2006 | |
28772-56-7 | 2H-1-benzopyran-2-one, 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy- | bromadiolone | Pesticide | HSC 2004 | |
32388-55-9 | ethanone, 1-(2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl)-, [3R-(3alpha,3abeta,7beta,8aalpha)] | 9-Acetyl-8-cedrene | Aromatic hydrocarbon | HSC 2004 | |
39083-38-0 | 2-hexene, 3,4,5,5-tetramethyl- | Aliphatic hydrocarbon | HSC 2004 | ||
39300-45-3 | 2-butenoic acid, 2(or 4)-isooctyl-4,6(or 2,6)-dinitrophenyl ester | dinocap | Pesticide | HSC 2004 | |
39515-41-8 | (RS)-alpha-cyano-3-phenoxybenzyl 2,2,3,3-tetramethylcyclopropanecarboxylate | Fenpropathrin | Pyretroid | HSC(1) 2006 | |
40487-42-1 | Benzenamine, N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitro- | pendimethalin | Pesticide | HSC(1) 2006 | |
40716-66-3 | 1,6,10-dodecatrien-3-ol, 3,7,11-trimethyl-, (E)- | Aliphatic hydrocarbon | HSC 2004 | ||
42576-02-3 | Benzoic acid, 5-(2,4-dichlorophenoxy)-2-nitro-, methyl ester | Bifenox | Pesticide | HSC 2009 | |
51630-58-1 | (RS)-alpha-cyano-3-phenoxybenzyl (RS)-2-(4-chlorophenyl)-3-methylbutyrate | fenvalerate | Pesticide | HSC 2005 | |
52315-07-8 | cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester | cypemethrin | Pesticide | HSC 2004 | |
52645-53-1 | cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester | permethrin | Pesticide | HSC 2004 | |
52918-63-5 | cyclopropanecarboxylic acid, 3-(2,2-dibromoethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester, [1R-[1.alpha.(S*),3.alpha.]]- | deltamethrin | Pesticide | HSC 2004 | |
53500-83-7 | oxiranecarboxylic acid, 3-methyl-3-[4-(2-methylpropyl)phenyl]-, 1-methylethyl ester | Aliphatic hydrocarbon | HSC 2004 | ||
54914-37-3 | cyclohexanemethanamine,1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene) amino] | HSC 2003 | |||
57018-04-9 | O-2,6-dichloro-4-methylphenyl O,O-dimethyl phosphorothioate | tolclofos-methyl | Pesticide | HSC 2005 | |
57499-57-7 | ethanone, 1-[1,6-dimethyl-4-(4-methyl-3-pentenyl)-3-cyclohexen-1-yl]- | Aliphatic hydrocarbon | HSC 2004 | ||
57966-95-7 | cymoxanil | SPS 2002 | |||
62199-62-6 | heptane, 2,2,4,4,6-pentamethyl- | Pesticide | HSC 2004 | ||
63059-55-2 | hexanoyl chloride, 2-[2,4-bis(1,1-dimethylpropyl)phenoxy]- | Aliphatic hydrocarbon | HSC 2004 | ||
64257-84-7 | (RS)-alpha-cyano-3-phenoxy-benzyl 2,2,3,3-tetramethylcyclopropane carboxylate | fenpropathrin | Pyretroid | HSC 2005 | |
66230-04-4 | (S)-alpha-cyano-3-phenoxybenzyl (S)-2-(4-chlorophenyl)-3-methylbutyrate | esfenvalerate | Pesticide | HSC 2005 | |
67375-30-8 | cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester, [1-alpha.(S*),3.alpha.]-(.+-.)- | alphacypermethrin | Pesticide | HSC 2004 | |
68359-37-5 | Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(4-fluoro-3-phenoxyphenyl)methyl ester | cyfluthrin | Pyretreid | HSC 2005 | |
68515-48-0 | 1,2-Benzenedicarboxylic acid, di-C8-10-branched alkyl esters, C9-rich | DINP | Phthalates | HSC(1) 2006 | |
68517-09-9 | ethanone, 1-(2-hydroxy-5-tert-nonylphenyl)-, oxime | Organic nitrogen compound | HSC 2004 | ||
68877-29-2 | cyclohexanol, (1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)- | bornylcyclohexanol | Aromatic hydrocarbon | HSC 2004 | |
74070-46-5 | Benzenamine, 2-chloro-6-nitro-3-phenoxy- | aclonifen | Aromatic amine | HSC 2005 | |
97280-83-6 | dodecene, branched | isododecene | Aliphatic hydrocarbon | HSC 2004 | |
111479-05-1 | Propaquizafop | Propaquizafop | Pesticide | HSC 2008 |
Substances removed from the OSPAR List of Chemicals for Priority Action
CAS No. | Name | Synonym | Function or use category | Deselected by | Note |
---|---|---|---|---|---|
77-47-4 | 1,3-Cyclopentadiene, 1,2,3,4,5,5-hexachloro- | Hexachlorocyclopentadiene (HCCP) | Aliphatic halogen | HSC 2005 | |
98-51-1 | Benzene, 1-(1,1-dimethylethyl)-4-methyl- | 4-tert-butyltoluene | Benzene | HSC 2005 | |
107-46-0 | Hexamethyldisiloxane | HMDS | Organosilicane | HSC(1) 2007 | |
603-35-0 | Phosphine, triphenyl- | triphenylphosphine | Phosphine | HSC 2005 | |
26761-40-0 | di-“isodecyl”phthalate | DIDP | Phthalate | HSC(1) 2006 | |
28553-12-0 | 1,2-Benzenedicarboxylic acid, diisononyl ester | DINP | Phthalate | HSC(1) 2006 | |
68515-48-0 | 1,2-Benzenedicarboxylic acid, di-C8-10-alkyl esters, branched | DINP | Phthalate | HSC(1) 2006 | |
68515-49-1 | 1,2-Benzenedicarboxylic acid, di-C9-11-branched alkyl esters, C10-rich | DIDP | Phthalate | HSC(1) 2006 |
Reasons for deselection
hexane, 1,6-diisocyanato-2,2,4-trimethyl- (CAS No. 16938-22-0)
Evaluation by the IGE
Hydrolysis of isocyanates is self-evident. Information on the principal degradation product indicates a low potential for bioaccumulation. The substance does not fulfil the B criterion.
Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl- (CAS No. 80-56-8)
Evaluation by the IGE
The PBT Working Group of the Technical Committee of the European Chemicals Bureau evaluated in 2004 "terpenes and terpenoids, turpentine-oil, alpha-pinene fraction" and concluded to de-list alpha-pinene (CAS No. 80-56-8) from the candidate PBT/vPvB list since it did not fulfil the criteria of the EU Technical Guidance Document. An assessment against the OSPAR PBT criteria led to the conclusion that the P-criterion is not fulfilled, while B and T criteria are fulfilled. Based on the low persistence of the substance, IGE recommended deselecting alpha-pinene from the OSPAR List of Substances of Possible Concern.
cyclohexane, 5-isocyanato-1(isocyanatomethyl)-1,3,3-trimethyl- (CAS No. 4098-71-9)
Evaluation by the IGE
Hydrolysis of isocyanates is self-evident. Information on the principal degradation product indicates a low potential for bioaccumulation. The substance does not fulfil the B criterion.
cymoxanil (CAS No. 57966-95-7)
Evaluation by IGE
A report provided by industry on bioaccumulation, log Kow, biodegradation and fish and invertebrate toxicity study, revealing that half life is only 32 hours and not > 30 days, toxicity values at 20 to 30 mg/l and BCF and Kow < 10 (not corresponding to log values) was sufficient. The substance does not fulfil the PBT criteria.
cyclohexanemethanamine,1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene) amino] (CAS No. 54914-37-3)
Evaluation by the IGE
Hydrolysis of this substance is not self-evident. However, industry provided background documentation on the hydrolysis over the pH range 4-9, which showed that substance hydrolyses rapidly. The substance does not fulfil the P criterion.
1,4-benzenediol, 2,5-bis(1,1-dimethylpropyl)- (CAS No. 79-74-3)
Evaluation by the IGE
The QSAR-DK: Syracuse Version of H. Loonen’s Simca Fragment non-linear MITI model calculation led to an initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. As BIOWIN3= 2.3344 is above the threshold of 2.2, the combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfill the persistence criterion. QSAR-DK concluded from BIOWIN1 and BIOWIN3 indicates that the substance is inherently biodegradable (more than 70%). The substance does not fulfil the P criterion.
7H-benz[de]anthracen-7-one, 3-bromo- (CAS No. 81-96-9)
Evaluation by the IGE
As BIOWIN3= 2.3750 is above the threshold of 2.2 and the QSAR-DK concluded from BIOWIN1 and BIOWIN3 indicates that the substance is inherently biodegradable more than 70%, the substance does not fulfil the P criterion.
naphthalene, 2-methyl- (CAS No. 91-57-6) – ß-methylnaphthalene
Evaluation by the IGE
Information from industry on biodegradability and bioaccumulation potential is sufficient although the whole reports with all raw data were not provided. The test results on bioaccumulation showed that this was a borderline case. The test results on biodegradation clearly showed half life below 50 days. The substance therefore does not fulfil the P criterion.
1,1'-biphenyl, 4,4'-dibromo- (CAS No. 92-86-4)
Evaluation by the IGE
The QSAR-DK: Syracuse Version of H. Loonen’s Simca Fragment non-linear MITI model calculation led to an initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. As BIOWIN3= 2.2377 is above the threshold of 2.2 and QSAR-DK concluded from BIOWIN1 and BIOWIN3 indicates that the substance is inherently biodegradable (more than 70%), the combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
acetic acid, (2,4,5-trichlorophenoxy)-, butyl ester (CAS No. 93-79-8) – butyl 2,4,5-T
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to an initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
acetic acid, (2,4,5-trichlorophenoxy)-, pentyl ester (CAS No. 120-39-8) – 2,4,5-T esters
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
3-heptene, 2,2,4,6,6-pentamethyl- (CAS No. 123-48-8)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1-phenanthrenecarboxylic acid, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, [1R-(1.alpha.,4a.beta.,4b.alpha.,10a.alpha.)]- (CAS No. 127-25-3) – abietic acid methyl ester
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1-phenanthrenemethanol, 1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a-dimethyl-7-(1-methylethyl)- (CAS No. 127-36-6)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
benzene, 1-chloro-4-(chlorophenylmethyl)- (CAS No. 134-83-8)
Evaluation by the IGE
As BIOWIN3 = 2.3174 is above the threshold of 2.2 and the QSAR-DK concluded from BIOWIN1 and BIOWIN3 indicates that the substance is inherently biodegradable more than 70%, the substance is considered as non persistent. The substance does not fulfil the P criterion.
7H-dibenzo[c,g]carbazole (CAS No. 194-59-2)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
13H-dibenzo[a,i]carbazole (CAS No. 239-64-5)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
androst-4-en-3-one, 17-[(1-oxoheptyl)oxy]-, (17.beta.)- (CAS No. 315-37-7) – testosterone-enantate- (INNM)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1H-3a,7-methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, [3R-(3alpha,3abeta,7beta,8aalpha)]- (CAS No. 469-61-4) – .alpha.-cedrene
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
2-butenoic acid, 3-methyl-, 2-(1-methylpropyl)-4,6-dinitrophenyl ester (CAS No. 485-31-4) – binapacryl
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
3-cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (R*,R*)- (CAS No. 515-69-5) – .alpha.-bisabolol
Evaluation by the IGE
Study reports on biodegradability and acute toxicity tests on fish and daphnids challenging the non fulfilment of the P and T criteria provided by industry were sufficient. It was concluded that the test on biodegradability is acceptable although the whole report with all raw data was not provided. The substance does not fulfil the P criterion.
With respect to the toxicity testing without a definitive water solubility, it is not possible to judge what level causes immobility or fish mortality. In the daphnid test, tests solutions were prepared via dilution of the highest concentrated solution. This could be only considered as valid if the water solubility was > 25 mg/l in this case. Industry provided assurances that the study for determining the aquatic toxicity for daphnids was performed according to OECD 202 (including concentration control analysis) and under GLP conditions. In this test an aqueous extract was tested and the resulting EC50 based on analytically determined values is 1.3 mg/L. Therefore, the substance does not fulfil the T criterion.
phosphorodithioic acid, S, S’-methylene O,O,O’,O’-tetraethyl ester (CAS No. 563-12-2) – ethion
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not inherently biodegradable (20-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
[1,1'-biphenyl]-4,4'-diamine, 3,3'-dichloro-, dihydrochloride (CAS No. 612-83-9)
Evaluation by the IGE
Recommended for deselection on the basis of both persistence and bioaccumulation data. As the NSDB denominator is 5, this means that the half life is less than 10 days. The QSAR-DK using EPIWIN 3.02 indicates a low bio-concentration factor of 59. The ECB existing chemicals TP280 indicated a BCF of 507. The substance fulfils neither the P nor the B criteria.
benzenamine, 2,3,4,5-tetrachloro- (CAS No. 634-83-3 )
Evaluation by the IGE
Recommended for deselection on the basis of bioaccumulation data. The QSAR-DK using EPIWIN 3.02 indicates a low bio-concentration factor of 389. The substance does not fulfil the B criteria.
1-phenanthrenemethanol, 1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1.alpha.,4a.beta.,4b.alpha.,10a.alpha.)]- (CAS No. 666-84-2)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
phosphorodithioic acid, S-[[(4-chlorophenyl)thio]methyl]O,O-diethyl ester (CAS No. 786-19-6) – carbophention
Evaluation by the IGE
The QSAR-DK: Syracuse version of H. Loonen’s Simca Fragment linear MITI model calculation led to the initial assessment "not readily biodegradable (20-50%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
phenanthrene, 9-chloro- (CAS No. 947-72-8)
Evaluation by the IGE
As BIOWIN3 = 2.5226 is above the threshold of 2.2 and the QSAR-DK concluded from BIOWIN1 and BIOWIN3 indicates that the substance is inherently biodegradable more than 70%, the substance is considered as non persistent. The substance does not fulfil the P criterion.
phosphoric acid, tris(methylphenyl) ester (CAS No. 1330-78-5) – tricresylphosphate
Evaluation by the IGE
Biodegradation and bioaccumulation data of existing chemicals (based on the CSCL Japan. Ed. by Chemicals Inspection & Testing Institute Japan, Tokyo, Japan Chemical Industry Ecology-Toxicology & Information Center (JETOC), 1992) led to the initial assessment "not readily biodegradable (20-70%)" as stated in the fact sheet. As BIOWIN3= 2.3774 is above the threshold of 2.2, BIOWIN2=1.000 is above the threshold of 0.5 and QSAR-DK concluded from BIOWIN1 and BIOWIN3 indicates that the substance is inherently biodegradable (more than 70%), the combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1,1'-biphenyl, 4,4'-dichloro- (CAS No. 2050-68-2)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to an initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1,4-benzenediamine, N,N'-bis(1,4-dimethylpentyl)- (CAS No. 3081-14-9)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
stannane, tributyl(1-oxododecyl)oxy- (CAS No. 3090-36-6) – tributyltin laurate
Evaluation by the IGE
The substance was initially assessed as being "not readily biodegradable (20-50%)", (biodegradation and bioaccumulation data of existing chemicals based on the CSCL Japan. Ed. by Chemicals Inspection & Testing Institute Japan, Tokyo, Japan Chemical Industry Ecology-Toxicology & Information Center (JETOC), 1992) as stated in the fact sheet. The NSDB denominator leads to the conclusion that the substance does not fulfil the P criterion.
cyclohexane, (1,1-dimethylethyl)- (CAS No. 3178-22-1)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criteria.
benzenamine, 2,3,5,6-tetrachloro- (CAS No. 3481-20-7)
Evaluation by the IGE
Recommended for deselection on the basis of bioaccumulation data. The QSAR-DK using EPIWIN 3.02 indicates a low bio-concentration factor of 288. The substance does not fulfil the B criterion.
1,4-pentadien-3-ol, 3-methyl-1-(2,6,6-trimethyl-1-cyclohexen-1-yl)- (CAS No. 5208-93-5) – vinyl-.beta.-ionol
Evaluation by the IGE
Test results on toxicity provided by industry were all obtained either with a solubilising agent or determined under non GLP conditions. In order to challenge the persistence criterion industry offered voluntarily to conduct a biodegradation study prior to SPS 2003. The EU technical meeting was contacted for advice on how to use the absence of toxic effects in acute tests at concentrations above the water solubility for the assessment of the toxicity criterion. EU-TM advised that expert judgement would need to be applied on a substance-by-substance basis. However, the new GLP study (OECD 301B) showed biodegradability (although not readily biodegradable) at half life lower than the OSPAR P criterion. The substance does not fulfil the P criterion.
2-butenoic acid, 2-(1-methylheptyl)-4,6-dinitrophenyl ester (CAS No. 6119-92-2)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1,6,10-dodecatrien-3-ol, 3,7,11-trimethyl- (CAS No. 7212-44-4) – nerolidol
Evaluation by the IGE
A study report on biodegradability provided by industry was accepted although the whole report with all raw data was not provided. The substance does not fulfil the P criterion.
Industry also provided values from the environmental effects database (EEDB obtained via contact point of the EPA-AQUIRE database) containing data on acute toxicity on fish and daphnids but no conclusion was drawn with respect to the toxicity values.
bromperidol (CAS No. 10457-90-6)
Evaluation by the IGE
Recommended for deselection on the basis of bioaccumulation data. The QSAR-DK using EPIWIN 3.02 indicates a low bio-concentration factor of 76. The substance does not fulfil the B criterion.
cedrene (CAS No. 11028-42-5)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1-phenanthrenemethanol, tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)- (CAS No. 13393-93-6) – abietyl alcohol, tetrahydro-
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
heptane, 2,2,4,6,6-pentamethyl- (CAS No. 13475-82-6)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
1,4-benzenediamine, N-(1-methylheptyl)-N'-phenyl- (CAS No. 15233-47-3)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
9,10-anthracenedione, 1,4-bis(butylamino)- (CAS No. 17354-14-2) – C.I. Solvent Blue 35
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
silane, trichloro(2,4,4-trimethylpentyl)- (CAS No. 18379-25-4)
Evaluation by the IGE
As BIOWIN3 = 2.4397 is above the threshold of 2.2 and the QSAR-DK concluded from BIOWIN1 and BIOWIN3 indicates that the substance is inherently biodegradable more than 70%, the substance is considered as non persistent. The substance does not fulfil the P criterion.
1-phenanthrenecarboxylic acid, tetradecahydro-1,4a-dimethyl-7-(1-methylethyl)-, methyl ester, [1R-(1.alpha.,4a.beta.,4b.alpha.,7.beta.,8a.beta.,10a.alpha.)]- (CAS No. 19941-28-7) – methyl tetrahydroabietate
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. A RIFM Private Communication of 1999 states that a biodegradability of 9.8-12.6 % was reached after 28 days in a OECD 301C test. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
3-cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, [S-(R1,R1)] (CAS No. 23089-26-1) – levomenol
Evaluation by the IGE
Levomenol is one enantiomere of the racemic mixture of bisabolol. Therefore the study reports for bisabolol are relevant. For bisabolol industry provided study reports on biodegradability and acute toxicity tests on fish and daphnids challenging the non fulfilment of the P and T criteria provided by industry. It was concluded that the test on biodegradability is acceptable although the whole report with all raw data was not provided. The substance does not fulfil the P criterion.
The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) also leads to the conclusion that the substance does not fulfil the P criterion.
3-cyclohexene-1-methanol, .alpha.,4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-, (R*,R*)-(.+-.)- (CAS No. 25428-43-7)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
2H-1-benzopyran-2-one, 3-[3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy- (CAS No. 28772-56-7) – bromadiolone
Evaluation by the IGE
The substance was initially selected based on the initial assessment "not readily biodegradable (20-50%)" (KemI Report 9/88. Solna, Sweden, Nationals Chemicals Inspectorate, 1988 (in Swedish)) as stated in the fact sheet. The NSDB Denominator lead to the conclusion that the substance does not fulfil the P criterion.
ethanone, 1-(2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl)-, [3R-(3alpha, 3abeta,7beta,8aalpha)] (CAS No. 32388-55-9) – 9-Acetyl-8-cedreme
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
2-hexene, 3,4,5,5-tetramethyl- (CAS No. 39083-38-0)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
2-butenoic acid, 2(or 4)-isooctyl-4,6(or 2,6)-dinitrophenyl ester (CAS No. 39300-45-3) – dinocap
Evaluation by IGE
Water-sediment studies with the radio-labelled substance shows shorter half life than previously known, and that the OSPAR P criterion is not met. The metabolites were further degraded and bound to the sediment before being mineralised. The substance does not fulfil the P criterion.
1,6,10-dodecatrien-3-ol, 3,7,11-trimethyl-, (E)- (CAS No. 40716-66-3)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
cypermethrin (CAS No. 52315-07-8) – cypermethrin
Evaluation by IGE
The selection was originally based on QSAR data. Water-sediment studies showed that the radio-labelled substance was rapidly degraded under both aerated and static conditions with a half life shorter than the OSPAR P criterion. The hydrolysis products are further degraded and not toxic. The substance does not fulfil the P criterion.
cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester (CAS No. 52645-53-1) – permethrin
Evaluation by the IGE
The substance was initially selected based on a half life of 20 days (Linders et al., report no 679101014 RIVM), which does not fulfil the persistence criterion. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) and the NSDB denominator lead to ambiguous results. Water-sediment studies with the radio-labelled substance show enough evidence to presume that the substance is not persistent in natural seawater and therefore does not fulfil the OSPAR P criterion.
cyclopropanecarboxylic acid, 3-(2,2-dibromoethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester, [1R-[1.alpha.(S*),3.alpha.]]- (CAS No. 52918-63-5) – deltamethrin
Evaluation by IGE
Water-sediment studies with the radio-labelled substance show enough evidence to presume that the substance is not persistent in natural seawater and therefore does not fulfil the OSPAR P criterion. The results of pond studies carried out under realistic conditions showed lower BCFs than the OSPAR B criterion. The substance does not fulfil the P and B criteria.
oxiranecarboxylic acid, 3-methyl-3-[4-(2-methylpropyl)phenyl]-, 1-methylethyl ester (CAS No. 53500-83-7)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
ethanone, 1-[1,6-dimethyl-4-(4-methyl-3-pentenyl)-3-cyclohexen-1-yl]- (CAS No. 57499-57-7)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
heptane, 2,2,4,4,6-pentamethyl- (CAS No. 62199-62-6)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
hexanoyl chloride, 2-[2,4-bis(1,1-dimethylpropyl)phenoxy]- (CAS No. 63059-55-2)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(3-phenoxyphenyl)methyl ester, [1-alpha.(S*),3.alpha.]-(.+-.)- (CAS No. 67375-30-8) – alphacypermethrin
Evaluation by the IGE
A comprehensive report on the environmental fate and aquatic ecotoxicological data was developed within the framework of Council Directive 91/414/EEC. In natural water sediment systems radio-labelled alphacypermethrin metabolised very fast with a half life below 50 days (mineralisation to CO2). The substance does not fulfil the P criterion.
ethanone, 1-(2-hydroxy-5-tert-nonylphenyl)-, oxime (CAS No. 68517-09-9)
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
cyclohexanol, (1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)- (CAS No. 68877-29-2) – bornylcyclohexanol
Evaluation by the IGE
The QSAR-DK: BIOWIN1 calculation led to the initial assessment "not readily biodegradable (50-70%)" as stated in the fact sheet. A RIFM Private Communication of 1999 states that a biodegradability of 9.8-12.6 % was reached after 28 days in a OECD 301C test. The combination of QSAR derived data as recommended in the TGD (combination of BIOWIN2/Mitideg2/BIOWIN3 models) leads to the conclusion that the substance does not fulfil the P criterion.
dodecene, branched (CAS No. 97280-83-6) – isododecene
Evaluation by IGE
BIOWIN model assessments of different isomers of the technical mixture isododecene showed that isododecene is not persistent. This is supported by the modified Sturm test (OECD guideline 302 B) on degradability of isooctene (di-n-butene), which has a similar structure in terms of branching and double bound to isododecene, because both olefins are produced by the same production process (di-, and triimerizing of n-butenes (but-1-ene and but-2-ene). A test report on the acute immobilisation test of Daphnia magna by triisobuten (isooctene) was accepted on the basis that a mixture of C12 and C8 substances had been tested and that the test is valid. The test result can be read as NOECimmobilisation =3.10 mg/l and EC50 (48 h, immobilisation) > 3.10 mg/l, which is at the limit of test-conditional water solubility. The tested substance is therefore not toxic for Daphnia. The substance does not fulfil the P and T criteria.
1,3,4-Oxadiazol-2(3H)-one, 3-[2,4-dichloro-5-(1-methylethoxy)phenyl]-5-(1,1-dimethylethyl)- (CAS No. 19666-30-9) – oxidiazon
Evaluation by the IGE (RS)-alpha-cyano-3-phenoxybenzyl (RS)-2-(4-chlorophenyl)-3-methylbutyrate (CAS No. 51630-58-1) – fenvalerate
Evaluation by the IGE
In new studies the overall half-life in water-sediment systems at 20 oC was shown to range from 20 to 40 days. Major metabolites were found to be decreasing towards the end of the study and BCFs calculated for these metabolites indicate that they are not liable to bioaccumulate. The substance does not meet the P criterion.
O-2,6-dichloro-4-methylphenyl O,O-dimethyl phosphorothioate (CAS No. 57018-04-9) – tolclofos-methyl
Evaluation by IGE
New studies showed that the overall half-life in water/sediment systems at 20 oC was 15-16 days. The primary metabolite also degraded significantly during the later stages of the incubation. Thus tolclofos-methyl does not meet the P criterion. The bioconcentration study indicated that BCF for tolclofos-methyl and its metabolites were below the cut-off value of 500, but these results were not conclusive.
(RS)-alpha-cyano-3-phenoxy-benzyl 2,2,3,3-tetramethylcyclopropane carboxylate (CAS No. 64257-84-7) – fenpropathrin
Evaluation by IGE
In three new water/sediment system studies the overall half-life at 20 oC was shown to be between 23 and 47 days. Major metabolites were found to be decreasing towards the end of the study and BCFs calculated for these metabolites indicate that they are not liable to bioaccumulate. Fenpropathrin does not meet the P criterion.
(S)-alpha-cyano-3-phenoxybenzyl (S)-2-(4-chlorophenyl)-3-methylbutyrate (CAS No. 66230-04-4) – esfenvalerate
Evaluation by IGE
Esfenvalerate is one of four optical isomers of fenvalerate. In two new water/sediment studies the overall half-life at 10 oC was between 65-79 days. Comparative information on the rates of biological degradation in aerobic soil allowed the conclusion that the biodegradability of esfenvalerate is similar to or perhaps even slightly faster than that of fenvalerate, for which the half-life in water/sediment systems at 20 oC had been shown to range from 20 to 40 days. Thus esfenvalerate does not meet the P criterion.
Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(4-fluoro-3-phenoxyphenyl)methyl ester (CAS No. 68359-37-5) – cyfluthrin
Evaluation by IGE
New documentation showed that cyfluthrin does not accumulate in water or sediment and that it appears to degrade rapidly in sediment. It does not fulfil the P criterion, and is borderline with regard to the B criterion.
Benzenamine, 2-chloro-6-nitro-3-phenoxy- (CAS No. 74070-46-5) – aclonifen
Evaluation by IGE
Detailed study reports showed that aclonifen does not fulfil the P criterion in the aqueous phase, but that unextraxtable residues in the sediment are highly persistent. The bound residues in the sediment were shown to be metabolites formed by microbial transformation of aclonifen, rather than binding of the parent compound itself. A chironomid toxicity test using spiked sediment led to the conclusion that the bound residues did not generate a concern for harm. It was therefore concluded that the substance does not fulfil the P criterion.
1,3-Cyclopentadiene, 1,2,3,4,5,5-hexachloro- (CAS No. 77-47-4) – hexachlorocyclopentadiene (HCCP)
Evaluation by the IGE and HSC 2005
HSC 2005 considered the information of the risk assessment report (RAR) prepared under the EU Council Regulation (EEC) 793/93, the Existing Substances Regulation, which was concluded after the adoption of the Background Document for HCCP. The RAR showed a half-life for hydrolysis at 12°C of 13,9 days and a bioconcentration factor less than 11. Thus the P and the B criteria are not fulfilled. HSC 2005 concluded that based on the strict use of the DYNAMEC criteria, the substance would not have been selected today. Furthermore there was no reason for selection of HCCP under the Safety Net Procedure. There is no evidence of widespread occurrence in the marine environment, and HCCP is not suspected of endocrine disruptive effects. Based on this the OSPAR Commission concluded to delete the substance from the OSPAR List of Chemicals for Priority Action and to update the List of Substances of Possible Concern accordingly.
Benzene, 1-(1,1-dimethylethyl)-4-methyl- (CAS No. 98-51-1) – 4-tert-butyltoluene
Evaluation by the IGE and HSC 2005
The substance was selected as a priority substance partly based on QSAR data. The substance does not meet the T acute criterion, as shown in the OSPAR fact sheet and Background Document published in 2003. Based on the strict use of the DYNAMEC criteria, the substance would not have been selected today, since non-fulfilment of the T acute criterion is sufficient to conclude that the substance is not a PBT substance. The Background Document describes 4-tert-butyltoluene as an intermediate used in closed systems and it is therefore not considered to be a risk for the marine environment. Furthermore it is not suspected to have endocrine disrupting effects. Based on this the OSPAR Commission concluded to delete the substance from the OSPAR List of Chemicals for Priority Action and to update the List of Substances of Possible Concern accordingly.
Hexamethyldisiloxane (HMDS) (CAS No. 107-46-0)
Evaluation by the IGE
HMDS was prioritised based on information in the EC/ECB existing substances evaluation, showing that it fulfilled the OSPAR PBT criteria. According to EU TGD criteria only the P criterion is likely to be fulfilled. IGE examined a new study on hydrolysis of HMDS submitted by the manufacturer. IGE concluded that the study showed that the P criterion was not fulfilled and that the hydrolysis products would evaporate and photo-oxidise. IGE considered that the monitoring data from the Background Document did not give a concern that would warrant any measures by OSPAR. Based on this the OSPAR Commission concluded that HMDS should be deselected.
Phosphine, triphenyl- (CAS No. 603-35-0) – triphenylphosphine
Evaluation by the IGE and HSC 2005
Based on the information in the Background Document for triphenylphosphine, which was published in 2003, it was concluded that the substance does not meet the T acute criterion. Based on a new study evaluated by the ECB PBT working group, HSC concluded that the B-criterion is not met either. The substance is an intermediate used in closed systems and it is therefore not considered to be a risk for the marine environment. Furthermore it is not suspected to have endocrine disrupting effects. Based on this the OSPAR Commission concluded to delete the substance from the OSPAR List of Chemicals for Priority Action and to update the List of Substances of Possible Concern accordingly.
Pendimethalin (CAS No. 40487-42-1)
Evaluation by IGE
Pendimethalin was originally selected since it fulfilled the PBT criteria. The P criterion was based on QSAR data. The producer supplied reports from new studies on degradation and effects in sediments in fresh water. The IGE concluded that the studies showed that pendimethalin was not meeting the P criterion, that no toxic effects on sediment dwelling organisms were demonstrated for the degradation products and bound residues, and that there was no evidence of risk to the marine environment leading to equivalent concern and that pendimethalin should therefore be deselected from the List of Substances of Possible Concern.
Fenpropathrin (CAS No. 39515-41-8)
Evaluation by IGE
The IGE recalled its evaluation in 2005 of three water/sediment systems studies in which the overall half-life at 20 oC was shown to be between 23 and 47 days. Major metabolites were found to be decreasing towards the end of the study and BCFs calculated for these metabolites indicate that they are not liable to bioaccumulate. The IGE had concluded that fenpropathrin (CAS No. 64257-84-7) does not meet the P criterion. Based on the newly submitted information that both listed CAS numbers for fenpropathrin were denoting the same substance, the IGE concluded that the decision by HSC in 2005 to deselect CAS No. 64257-84-7 implied that also CAS No. 39515-41-8 should be removed from the List of Substances of Possible Concern.
Propaquizafop (CAS No. 111479-05-1)
Evaluation by IGE
IGE assessed both the parent molecule and the hydrolysis product propaquizafop acid for PBT properties. The available experimental studies indicated that the T-criterion was fulfilled and that the B-criterion was just above the cut-off value applied by OSPAR. However, the rapid depuration reduced the concern for bioaccumulation. The key issue in the assessment of persistence of propaquizafop was the character of the bound residues which formed during the biodegradation test using a water-sediment system. The ample information on metabolites that was acquired in the study, the demonstration of considerable mineralization, evidence that bound residues originated from a non-toxic metabolite, and evidence that some radio-labeled carbon had ended up in bacteria and therefore could be biodegraded, was considered to be a sufficient basis for reasonably ruling out a significant potential toxic effect of the bound residues. On this basis, IGE concluded that propaquizafop did not fulfill the P-criterion and therefore was not PBT according to the OSPAR criteria, and since the substance did not give reason for an equivalent level of concern, IGE recommended deselection from the List of Substances of Possible Concern.
TBBPA-DBPE (CAS No. 21850-44-2)
Evaluation by IGE
IGE concluded that there was sufficient evidence that the B- and T-criterion were not fulfilled. In view of recent experience with other brominated flame retardants, in particular decabromodiphenylether (DBDE), giving rise to an equivalent level of concern as a PBT-substance, IGE examined additional toxicological studies. IGE concluded that the available scientific evidence was insufficient to support conclusions on ecotoxic properties of the substance, and too limited to justify “equivalent” level of concern for keeping TBBPA-DBPE selected.
Bifenox (CAS No. 42576-02-3)
Evaluation by IGE
Bifenox does not fulfil the P criterion, but there was a concern about the bound residues of bifenox metabolites in the sediment. Further studies showed that none of the metabolites of bifenox fulfilled the T criterion. It was concluded that even in the case that bound residues might revert under certain conditions to free bifenox metabolites, no significant harmful effects were to be expected.
Phthalates DINP (CAS No 68515-48-0 and 28553-12-0) and DIDP (CAS No 68515-49-1 and 26761-40-0)
Evaluation by IGE
DINP and DIDP are not PBT substances according to OSPAR DYNAMEC or EU-TGD criteria and there is no indication of potential for endocrine disruption. Both substances have a potential for food chain transfer in marine mammals but their current use patterns and concentrations in the environment suggest that no long-term effects and no endocrine disrupting effect in the aquatic environment are expected. The IGE concluded that DIDP should be removed from the List of Chemicals for Priority Action (DIDP was never placed on the List of Substances of Possible concern) and that DINP should be removed from both lists.